The manufacturer of our Estradiol assay has updated its standardization to the international reference method of isotope dilution gas chromatography mass spectrometry (ID-GCMS) method from the USP reference material. As a result, there are some changes to the reference ranges for patients as determined by the manufacturer.
|Current Ref Range||New Ref Range|
|Males||20-75 pg/mL||<48 pg/mL|
|Post-menopausal Females||20-88 pg/mL||<41 pg/mL|
|Mid follicular phase||24-114 pg/mL||27-122 pg/mL|
|Mid luteal phase||80-273 pg/mL||49-291 pg/mL|
|Peri-ovulatory phase||62-534 pg/mL||95-433 pg/mL|
Reported values with this assay below 40 pg/mL must be interpreted with caution as the analytical variability (expressed as CV; coefficient of variation) remains >20% at these concentrations. If you would like further information, please call Linda Gaede (925) 692-5633, Pat Sinz (925) 692-5631, or me (925) 674-2508. Thank you.